Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain

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Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain.

A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, ...

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ژورنال

عنوان ژورنال: Acta Pharmaceutica

سال: 2016

ISSN: 1846-9558

DOI: 10.1515/acph-2016-0020